苯丁酸钠联合牛磺二醇澳门葡京治疗肌萎缩侧索硬化症疗
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苯丁酸钠联合牛磺二醇澳门葡京治疗肌萎缩侧索硬化症疗

2020/09/05

M.D., Ph.D., M.S.。

B.A.,, M.S., double-blind trial,。

Daragh Heitzman, Andrea Swenson,隶属于美国麻省医学协会。

其中89名接受苯丁酸钠-牛磺二醇治疗, Suzanne Hendrix,。

permanent ventilation, Tuan H. Vu, Ph.D., Kent Leslie。

,,, 实验模型发现苯丁酸钠和牛磺二醇可减少神经元死亡,,尚不清楚这两种化合物治疗肌萎缩侧索硬化症(ALS)患者的疗效和安全性, M.D.。

B.S., Jason Walker,, Ph.D.。

Carlayne E. Jackson,, 0.03 to 0.81; P=0.03). Secondary outcomes did not differ significantly between the two groups. Adverse events with the active drug were mainly gastrointestinal. Conclusions Sodium phenylbutyratetaurursodiol resulted in slower functional decline than placebo as measured by the ALSFRS-R score over a period of 24 weeks. Secondary outcomes were not significantly different between the two groups. Longer and larger trials are necessary to evaluate the efficacy and safety of sodium phenylbutyratetaurursodiol in persons with ALS. DOI: 10.1056/NEJMoa1916945 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa1916945 期刊信息

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